Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3343143..3343848 Replicon chromosome
Accession NZ_CP103657
Organism Escherichia coli strain 3150

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M5R25_RS16115 Protein ID WP_000539521.1
Coordinates 3343143..3343529 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5R25_RS16120 Protein ID WP_001280945.1
Coordinates 3343519..3343848 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R25_RS16095 (3339147) 3339147..3339773 + 627 WP_001295292.1 glutathione S-transferase GstB -
M5R25_RS16100 (3339770) 3339770..3340885 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
M5R25_RS16105 (3340996) 3340996..3341379 - 384 WP_000497137.1 biofilm formation regulator BssR -
M5R25_RS16110 (3341592) 3341592..3342917 + 1326 WP_129666835.1 30S ribosomal protein S12 methylthiotransferase RimO -
M5R25_RS16115 (3343143) 3343143..3343529 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5R25_RS16120 (3343519) 3343519..3343848 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M5R25_RS16125 (3343918) 3343918..3345246 - 1329 WP_022645414.1 GGDEF domain-containing protein -
M5R25_RS16130 (3345254) 3345254..3347602 - 2349 WP_022645413.1 EAL domain-containing protein -
M5R25_RS16135 (3347779) 3347779..3348690 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T256052 WP_000539521.1 NZ_CP103657:3343143-3343529 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT256052 WP_001280945.1 NZ_CP103657:3343519-3343848 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References