Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2398518..2399194 Replicon chromosome
Accession NC_015942
Organism Acidithiobacillus ferrivorans SS3

Toxin (Protein)


Gene name vapC Uniprot ID G0JPF4
Locus tag ACIFE_RS11475 Protein ID WP_014029745.1
Coordinates 2398518..2398943 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1E7XR03
Locus tag ACIFE_RS11480 Protein ID WP_041649606.1
Coordinates 2398940..2399194 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIFE_RS11450 2394832..2395803 - 972 WP_141672349.1 D-alanyl-D-alanine carboxypeptidase -
ACIFE_RS11455 2395952..2396713 + 762 WP_014029743.1 sulfite exporter TauE/SafE family protein -
ACIFE_RS11460 2396729..2397736 + 1008 WP_014029744.1 class I SAM-dependent methyltransferase -
ACIFE_RS17345 2398130..2398336 + 207 WP_202796624.1 hypothetical protein -
ACIFE_RS11475 2398518..2398943 - 426 WP_014029745.1 type II toxin-antitoxin system VapC family toxin Toxin
ACIFE_RS11480 2398940..2399194 - 255 WP_041649606.1 Arc family DNA-binding protein Antitoxin
ACIFE_RS17350 2399285..2399473 - 189 WP_197052788.1 BrnT family toxin -
ACIFE_RS11490 2399853..2400176 + 324 WP_014029747.1 transcriptional regulator -
ACIFE_RS11495 2400243..2402981 + 2739 WP_014029748.1 type I restriction endonuclease subunit R -
ACIFE_RS11500 2403026..2404114 + 1089 WP_014029749.1 virulence RhuM family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15189.80 Da        Isoelectric Point: 7.1661

>T25605 WP_014029745.1 NC_015942:c2398943-2398518 [Acidithiobacillus ferrivorans SS3]
MILLDTNVISEPLRKAPEICVVTWIDAQPIETLYLSTVTIAELRLGIAMLPTGRRRDILHENLEDRVLPMFVGRVLAFDL
AASQAFAHLMAKSRGAGFAIGRADGYIAAIAAANKMTVATRDTGPFLSAGITVINPWALSA

Download         Length: 426 bp

>T25605 NC_015942:c2398943-2398518 [Acidithiobacillus ferrivorans SS3]
ATGATTCTTCTCGATACCAATGTCATTTCGGAACCCCTGCGAAAAGCGCCCGAGATATGCGTTGTCACCTGGATCGATGC
GCAACCCATTGAGACTCTTTATCTTTCAACTGTCACCATTGCTGAGTTACGACTGGGTATTGCAATGCTGCCGACTGGTC
GGCGCCGGGATATCCTCCACGAGAATCTGGAAGACCGTGTGCTGCCCATGTTTGTCGGGCGGGTGCTGGCATTTGACCTG
GCTGCCTCGCAGGCTTTCGCGCATTTAATGGCAAAATCTCGGGGTGCCGGTTTTGCCATTGGCAGGGCGGATGGTTACAT
CGCAGCGATTGCTGCCGCCAATAAAATGACTGTAGCCACGAGGGATACTGGCCCGTTCCTGTCTGCCGGGATAACAGTCA
TCAATCCATGGGCATTATCGGCGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9670.11 Da        Isoelectric Point: 7.0205

>AT25605 WP_041649606.1 NC_015942:c2399194-2398940 [Acidithiobacillus ferrivorans SS3]
MAMLTIRNLPEEVRRALRMRAAQHGRSTEAEVRSILEEVVKPQGRVKLGSLLTEIGRRADLTDEDLAVFERVRDKTPEEP
VRFE

Download         Length: 255 bp

>AT25605 NC_015942:c2399194-2398940 [Acidithiobacillus ferrivorans SS3]
ATGGCGATGCTGACTATACGGAATCTTCCTGAAGAAGTTCGGCGTGCATTGCGTATGCGTGCCGCACAGCATGGGCGAAG
CACTGAGGCTGAGGTCCGATCGATATTAGAAGAAGTAGTGAAGCCACAGGGGCGGGTGAAGCTGGGGTCACTATTGACTG
AGATTGGCCGTCGCGCCGATCTGACCGATGAAGATCTTGCGGTATTCGAGCGGGTGCGCGATAAGACTCCTGAAGAGCCG
GTACGTTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060UUA7

Antitoxin

Source ID Structure
AlphaFold DB A0A1E7XR03

References