Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1018326..1018980 Replicon chromosome
Accession NZ_CP103657
Organism Escherichia coli strain 3150

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag M5R25_RS04885 Protein ID WP_000244781.1
Coordinates 1018573..1018980 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag M5R25_RS04880 Protein ID WP_001564007.1
Coordinates 1018326..1018592 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R25_RS04860 (1014414) 1014414..1015847 - 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -
M5R25_RS04865 (1015892) 1015892..1016203 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
M5R25_RS04870 (1016367) 1016367..1017026 + 660 WP_000250274.1 hemolysin III family protein -
M5R25_RS04875 (1017103) 1017103..1018083 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
M5R25_RS04880 (1018326) 1018326..1018592 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
M5R25_RS04885 (1018573) 1018573..1018980 + 408 WP_000244781.1 protein YgfX Toxin
M5R25_RS04890 (1019020) 1019020..1019541 - 522 WP_001055874.1 flavodoxin FldB -
M5R25_RS04895 (1019653) 1019653..1020549 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5R25_RS04900 (1020574) 1020574..1021284 + 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5R25_RS04905 (1021290) 1021290..1023023 + 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T256043 WP_000244781.1 NZ_CP103657:1018573-1018980 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT256043 WP_001564007.1 NZ_CP103657:1018326-1018592 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References