Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 2229556..2230081 Replicon chromosome
Accession NC_015942
Organism Acidithiobacillus ferrivorans SS3

Toxin (Protein)


Gene name stbE Uniprot ID G0JNN0
Locus tag ACIFE_RS10795 Protein ID WP_014029620.1
Coordinates 2229800..2230081 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0JNM9
Locus tag ACIFE_RS10790 Protein ID WP_014029619.1
Coordinates 2229556..2229810 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIFE_RS10770 2225120..2227471 + 2352 WP_014029615.1 type I restriction-modification system subunit M -
ACIFE_RS15890 2227462..2228760 + 1299 WP_014029616.1 restriction endonuclease subunit S -
ACIFE_RS10780 2228806..2229156 + 351 WP_014029617.1 type II toxin-antitoxin system RelE/ParE family toxin -
ACIFE_RS10785 2229153..2229467 + 315 WP_014029618.1 helix-turn-helix domain-containing protein -
ACIFE_RS10790 2229556..2229810 + 255 WP_014029619.1 antitoxin Antitoxin
ACIFE_RS10795 2229800..2230081 + 282 WP_014029620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACIFE_RS10800 2230085..2233162 + 3078 WP_014029621.1 type I restriction endonuclease subunit R -
ACIFE_RS10805 2233152..2233892 + 741 WP_014029622.1 M48 family metallopeptidase -
ACIFE_RS16415 2233966..2234295 + 330 Protein_2164 H-NS histone family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10764.64 Da        Isoelectric Point: 10.6855

>T25604 WP_014029620.1 NC_015942:2229800-2230081 [Acidithiobacillus ferrivorans SS3]
MLYELTFHPSALKEWQALDHSVRAPFKKKLAERLVHPRVPSAQLQGHPDRYKIKLRSIGYRLIYQVMETEVQVLVLAVGK
REGSVAYHKAKGR

Download         Length: 282 bp

>T25604 NC_015942:2229800-2230081 [Acidithiobacillus ferrivorans SS3]
ATGCTTTATGAGCTCACTTTCCATCCCTCTGCCCTCAAAGAATGGCAGGCCTTGGACCATAGCGTCCGTGCCCCATTCAA
AAAGAAACTGGCAGAACGCTTAGTGCACCCACGCGTCCCTTCCGCTCAACTGCAGGGCCACCCGGATCGCTACAAGATCA
AACTCCGCAGCATAGGCTATCGCTTGATCTACCAAGTGATGGAAACGGAAGTCCAAGTGTTGGTCCTGGCGGTAGGCAAG
CGGGAAGGCTCTGTCGCCTATCACAAAGCCAAAGGACGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8833.14 Da        Isoelectric Point: 4.4778

>AT25604 WP_014029619.1 NC_015942:2229556-2229810 [Acidithiobacillus ferrivorans SS3]
MTHVILADVAASVSELKKNPMGTVAAGEGATVAILNRNEPAFYCVPAATYAALLEHLEDLELNALAESRLKDGQTPIKVS
LDAL

Download         Length: 255 bp

>AT25604 NC_015942:2229556-2229810 [Acidithiobacillus ferrivorans SS3]
ATGACCCACGTCATTCTTGCCGATGTTGCTGCCAGTGTTTCCGAACTCAAAAAGAACCCTATGGGAACCGTGGCCGCAGG
AGAAGGGGCTACTGTGGCCATTCTCAACCGCAACGAACCGGCTTTTTACTGTGTCCCAGCCGCTACCTATGCTGCGCTTC
TGGAACACCTGGAAGATTTGGAGCTGAACGCTTTGGCGGAAAGCCGTCTGAAGGATGGCCAAACCCCGATCAAGGTGTCG
CTGGATGCTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7XVG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E7XVG5

References