Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 5785..6310 Replicon plasmid pMB5730_1
Accession NZ_CP103655
Organism Klebsiella pneumoniae strain 1159

Toxin (Protein)


Gene name ccdB Uniprot ID W8UQV6
Locus tag M5S75_RS26050 Protein ID WP_001568026.1
Coordinates 5785..6090 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag M5S75_RS26055 Protein ID WP_001568025.1
Coordinates 6092..6310 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S75_RS26020 (M5S75_26020) 1501..2127 + 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -
M5S75_RS26025 (M5S75_26025) 2124..2426 + 303 WP_004197636.1 hypothetical protein -
M5S75_RS26030 (M5S75_26030) 2866..3660 - 795 WP_004197635.1 site-specific integrase -
M5S75_RS26035 (M5S75_26035) 3858..4874 - 1017 WP_020315256.1 hypothetical protein -
M5S75_RS26040 (M5S75_26040) 4871..5194 - 324 WP_022644730.1 hypothetical protein -
M5S75_RS26045 (M5S75_26045) 5221..5616 - 396 WP_017899885.1 hypothetical protein -
M5S75_RS26050 (M5S75_26050) 5785..6090 - 306 WP_001568026.1 type II toxin-antitoxin system toxin CcdB Toxin
M5S75_RS26055 (M5S75_26055) 6092..6310 - 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
M5S75_RS26060 (M5S75_26060) 6971..7675 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
M5S75_RS26065 (M5S75_26065) 7730..10264 + 2535 Protein_10 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / catA2 / dfrA14 - 1..75285 75285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11645.32 Da        Isoelectric Point: 5.6919

>T256039 WP_001568026.1 NZ_CP103655:c6090-5785 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT256039 WP_001568025.1 NZ_CP103655:c6310-6092 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EZN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References