Detailed information of TA system TA025603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 2228806..2229467
• Replicon: chromosome
• Accession: NC_015942
• Organism: Acidithiobacillus ferrivorans SS3

Toxin (Protein)

• Gene name: tad
• Uniprot ID: G0JNM7
• Locus tag: ACIFE_RS10780
• Protein ID: WP_014029617.1
• Coordinates: 2228806..2229156 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: ACIFE_RS10785
• Protein ID: WP_014029618.1
• Coordinates: 2229153..2229467 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACIFE_RS10765	2223893..2225065	+	1173	WP_014029614.1	SIR2 family protein	-
ACIFE_RS10770	2225120..2227471	+	2352	WP_014029615.1	type I restriction-modification system subunit M	-
ACIFE_RS15890	2227462..2228760	+	1299	WP_014029616.1	restriction endonuclease subunit S	-
ACIFE_RS10780	2228806..2229156	+	351	WP_014029617.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACIFE_RS10785	2229153..2229467	+	315	WP_014029618.1	helix-turn-helix domain-containing protein	Antitoxin
ACIFE_RS10790	2229556..2229810	+	255	WP_014029619.1	antitoxin	-
ACIFE_RS10795	2229800..2230081	+	282	WP_014029620.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ACIFE_RS10800	2230085..2233162	+	3078	WP_014029621.1	type I restriction endonuclease subunit R	-
ACIFE_RS10805	2233152..2233892	+	741	WP_014029622.1	M48 family metallopeptidase	-
ACIFE_RS16415	2233966..2234295	+	330	Protein_2164	H-NS histone family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-87)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12926.78 Da
• Isoelectric Point: 9.4003

>T25603 WP_014029617.1 NC_015942:2228806-2229156 [Acidithiobacillus ferrivorans SS3]
MKALAWVASARKDLKALPEEVQDVFGYALFLAQTGEKHDQAKPLKGFGSAGVLEVVEDHKGDTYRAVYTVRFEHAVYVLH
CFQKKSAQGKATPKPDMDLIHTRLQAAEKDARGRTQ

Nucleotide

• Length: 351 bp

>T25603 NC_015942:2228806-2229156 [Acidithiobacillus ferrivorans SS3]
ATGAAAGCTCTTGCTTGGGTAGCCTCCGCCAGAAAGGACCTGAAGGCCCTACCCGAAGAGGTTCAGGACGTTTTTGGCTA
CGCCCTGTTCCTGGCCCAGACAGGGGAAAAGCACGATCAAGCCAAACCCCTCAAGGGTTTTGGCTCTGCCGGTGTCCTGG
AAGTTGTGGAGGATCACAAAGGTGATACTTACCGCGCCGTGTACACGGTTCGCTTTGAACATGCCGTCTATGTGCTCCAC
TGCTTCCAGAAGAAGTCCGCCCAAGGCAAGGCCACACCGAAACCGGACATGGATTTGATTCACACCCGTTTACAGGCAGC
CGAAAAGGATGCCAGAGGCAGGACACAATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11412.26 Da
• Isoelectric Point: 5.6713

>AT25603 WP_014029618.1 NC_015942:2229153-2229467 [Acidithiobacillus ferrivorans SS3]
MNDEVIEMSTGNVYVDLDFVDAESMLLKAQLAARISHILTEKGWSQTQSAQVLGIPQSKLSMMLRGQFRGISEAKMLECL
ARLGRDIRIAIGPEHAGVGQVQVI

Nucleotide

• Length: 315 bp

>AT25603 NC_015942:2229153-2229467 [Acidithiobacillus ferrivorans SS3]
ATGAACGATGAAGTCATTGAAATGAGTACAGGCAATGTATACGTAGACCTGGATTTCGTTGATGCCGAGTCCATGCTGCT
CAAGGCACAATTGGCGGCACGTATCAGCCATATTCTCACGGAAAAAGGCTGGTCTCAGACGCAGTCGGCGCAAGTGCTGG
GCATCCCTCAGTCCAAGCTTTCCATGATGCTGCGGGGGCAATTCCGGGGGATCAGCGAAGCCAAAATGCTGGAATGTCTG
GCCAGACTCGGGCGGGATATCCGCATTGCCATCGGCCCGGAACATGCGGGAGTTGGACAGGTCCAGGTGATTTAA

Structures

Toxin

• AlphaFold DB: A0A1E7XVU7