Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 77261..77783 Replicon plasmid pMB5823_2
Accession NZ_CP103647
Organism Escherichia coli strain 961

Toxin (Protein)


Gene name relE Uniprot ID S1PVW2
Locus tag M5R18_RS25415 Protein ID WP_001681795.1
Coordinates 77502..77783 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1Q9V6
Locus tag M5R18_RS25410 Protein ID WP_001681796.1
Coordinates 77261..77512 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R18_RS25385 (M5R18_25385) 72677..73384 - 708 WP_001114349.1 A24 family peptidase -
M5R18_RS25390 (M5R18_25390) 73344..73826 - 483 WP_001681690.1 lytic transglycosylase domain-containing protein -
M5R18_RS25395 (M5R18_25395) 73874..74410 - 537 WP_001011500.1 type 4 pilus major pilin -
M5R18_RS25400 (M5R18_25400) 74460..75560 - 1101 WP_001211427.1 type II secretion system F family protein -
M5R18_RS25405 (M5R18_25405) 75562..77070 - 1509 WP_012605185.1 ATPase, T2SS/T4P/T4SS family -
M5R18_RS25410 (M5R18_25410) 77261..77512 + 252 WP_001681796.1 hypothetical protein Antitoxin
M5R18_RS25415 (M5R18_25415) 77502..77783 + 282 WP_001681795.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5R18_RS25420 (M5R18_25420) 78093..78545 - 453 WP_001681794.1 type IV pilus biogenesis protein PilP -
M5R18_RS25425 (M5R18_25425) 78535..79830 - 1296 WP_032325932.1 type 4b pilus protein PilO2 -
M5R18_RS25430 (M5R18_25430) 79851..81470 - 1620 WP_016238165.1 PilN family type IVB pilus formation outer membrane protein -
M5R18_RS25435 (M5R18_25435) 81501..81938 - 438 WP_001681791.1 type IV pilus biogenesis protein PilM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..90382 90382


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11122.01 Da        Isoelectric Point: 10.6249

>T256023 WP_001681795.1 NZ_CP103647:77502-77783 [Escherichia coli]
MTYELEFERRALKEWHKLGHTVREQFKKKLSERLKNPRVPAARLHGHTDRYKIKLRASGYRLVYQVIDEKIVLLVIAVGK
RESSEVYQMADIR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9124.33 Da        Isoelectric Point: 4.0610

>AT256023 WP_001681796.1 NZ_CP103647:77261-77512 [Escherichia coli]
MSYQILTTTAASITELKKNPMGTVAEGEGGAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVKVSL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PVW2

Antitoxin

Source ID Structure
AlphaFold DB S1Q9V6

References