Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1781..2328 Replicon plasmid pMB5823_2
Accession NZ_CP103647
Organism Escherichia coli strain 961

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag M5R18_RS24980 Protein ID WP_001384452.1
Coordinates 2050..2328 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag M5R18_RS24975 Protein ID WP_032181987.1
Coordinates 1781..2050 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R18_RS24970 (M5R18_24970) 1..873 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
M5R18_RS24975 (M5R18_24975) 1781..2050 + 270 WP_032181987.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
M5R18_RS24980 (M5R18_24980) 2050..2328 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
M5R18_RS24985 (M5R18_24985) 2368..3216 + 849 WP_032181988.1 3'-5' exonuclease -
M5R18_RS24990 (M5R18_24990) 3333..3806 + 474 WP_001334658.1 hypothetical protein -
M5R18_RS24995 (M5R18_24995) 4283..4549 - 267 WP_000627831.1 hypothetical protein -
M5R18_RS25000 (M5R18_25000) 4549..5025 - 477 WP_032182001.1 hypothetical protein -
M5R18_RS25005 (M5R18_25005) 5081..5683 - 603 WP_259425782.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..90382 90382


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T256022 WP_001384452.1 NZ_CP103647:2050-2328 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10177.47 Da        Isoelectric Point: 6.7251

>AT256022 WP_032181987.1 NZ_CP103647:1781-2050 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVEQQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure

References