Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 2221754..2222394 Replicon chromosome
Accession NC_015942
Organism Acidithiobacillus ferrivorans SS3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ACIFE_RS10755 Protein ID WP_202796619.1
Coordinates 2222002..2222394 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag ACIFE_RS10750 Protein ID WP_014029608.1
Coordinates 2221754..2221990 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIFE_RS10725 2217587..2218696 + 1110 WP_014029601.1 ABC transporter permease -
ACIFE_RS10730 2218883..2219173 + 291 WP_014029602.1 integration host factor subunit alpha -
ACIFE_RS10735 2219235..2219468 - 234 WP_014029603.1 hypothetical protein -
ACIFE_RS10740 2219830..2220579 + 750 WP_014029604.1 PilZ domain-containing protein -
ACIFE_RS16410 2220748..2220909 + 162 WP_014029605.1 type I restriction-modification system subunit M -
ACIFE_RS10745 2221042..2221554 + 513 WP_014029606.1 pyridoxamine 5'-phosphate oxidase family protein -
ACIFE_RS10750 2221754..2221990 + 237 WP_014029608.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ACIFE_RS10755 2222002..2222394 + 393 WP_202796619.1 type II toxin-antitoxin system VapC family toxin Toxin
ACIFE_RS17145 2222692..2222850 + 159 WP_158306938.1 hypothetical protein -
ACIFE_RS10760 2222983..2223903 + 921 WP_014029613.1 restriction endonuclease -
ACIFE_RS10765 2223893..2225065 + 1173 WP_014029614.1 SIR2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-115)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14415.64 Da        Isoelectric Point: 4.4857

>T25602 WP_202796619.1 NC_015942:2222002-2222394 [Acidithiobacillus ferrivorans SS3]
MLDTNMCIYLMKNQPEEVAKRFALCYVGDVVMSSITYAELTYGVAAANDPEQERINLASLVDDIQVAPFDIAAGVSYGPI
RLATRDTRKYALDKLIAAHAISLNVIIVTNNTKDFIKYPGAILENWLLET

Download         Length: 393 bp

>T25602 NC_015942:2222002-2222394 [Acidithiobacillus ferrivorans SS3]
ATGCTCGACACCAATATGTGCATTTACCTGATGAAGAATCAGCCAGAAGAAGTCGCCAAGCGTTTTGCACTGTGCTACGT
CGGCGATGTCGTGATGTCCTCAATCACCTACGCCGAACTGACATACGGTGTGGCCGCCGCAAACGATCCGGAACAAGAAC
GCATCAACCTTGCCAGCCTGGTGGATGATATACAGGTGGCTCCGTTTGATATTGCTGCCGGTGTATCCTACGGTCCCATC
CGGTTAGCTACCCGTGACACCAGGAAATATGCGCTCGACAAGCTGATTGCCGCACATGCTATATCGCTGAACGTGATTAT
CGTAACCAACAACACAAAGGACTTCATCAAATATCCAGGGGCGATTTTGGAAAATTGGCTTCTCGAAACATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9023.17 Da        Isoelectric Point: 5.8432

>AT25602 WP_014029608.1 NC_015942:2221754-2221990 [Acidithiobacillus ferrivorans SS3]
MHTTRIFKNGNSQAVRIPADIAYERTDMDLEIERDGDEIRIRPARRSLSMVLTKFARFAPDFMAEGRGDQQQAERDPL

Download         Length: 237 bp

>AT25602 NC_015942:2221754-2221990 [Acidithiobacillus ferrivorans SS3]
ATGCATACCACCCGAATTTTCAAGAACGGGAACTCACAGGCCGTCCGTATCCCGGCGGATATCGCCTATGAGCGCACCGA
CATGGATTTGGAGATTGAGCGTGATGGCGATGAAATCCGGATACGACCCGCGCGTCGGTCTTTGTCTATGGTGCTGACCA
AGTTTGCCAGGTTCGCCCCGGACTTCATGGCTGAAGGTCGCGGCGACCAGCAACAGGCAGAGAGAGACCCTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References