Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4268831..4269426 Replicon chromosome
Accession NZ_CP103645
Organism Escherichia coli strain 961

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5R18_RS20670 Protein ID WP_000239579.1
Coordinates 4268831..4269181 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5R18_RS20675 Protein ID WP_001223208.1
Coordinates 4269175..4269426 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R18_RS20650 (4264277) 4264277..4265299 - 1023 WP_001295197.1 ABC transporter permease -
M5R18_RS20655 (4265313) 4265313..4266815 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
M5R18_RS20660 (4266955) 4266955..4267911 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5R18_RS20665 (4268221) 4268221..4268751 + 531 WP_000055072.1 inorganic diphosphatase -
M5R18_RS20670 (4268831) 4268831..4269181 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5R18_RS20675 (4269175) 4269175..4269426 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5R18_RS20680 (4269638) 4269638..4269979 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5R18_RS20685 (4269982) 4269982..4273761 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T256012 WP_000239579.1 NZ_CP103645:c4269181-4268831 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT256012 WP_001223208.1 NZ_CP103645:c4269426-4269175 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References