Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2475504..2476142 Replicon chromosome
Accession NZ_CP103645
Organism Escherichia coli strain 961

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag M5R18_RS11990 Protein ID WP_001447010.1
Coordinates 2475966..2476142 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5R18_RS11985 Protein ID WP_001270286.1
Coordinates 2475504..2475920 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R18_RS11965 (2470656) 2470656..2471597 - 942 WP_001251304.1 ABC transporter permease -
M5R18_RS11970 (2471598) 2471598..2472611 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
M5R18_RS11975 (2472629) 2472629..2473774 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M5R18_RS11980 (2474019) 2474019..2475425 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M5R18_RS11985 (2475504) 2475504..2475920 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5R18_RS11990 (2475966) 2475966..2476142 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5R18_RS11995 (2476364) 2476364..2476594 + 231 WP_000494244.1 YncJ family protein -
M5R18_RS12000 (2476686) 2476686..2478647 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5R18_RS12005 (2478720) 2478720..2479256 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M5R18_RS12010 (2479309) 2479309..2480523 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T256005 WP_001447010.1 NZ_CP103645:c2476142-2475966 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT256005 WP_001270286.1 NZ_CP103645:c2475920-2475504 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References