Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 2062481..2063244 Replicon chromosome
Accession NC_015942
Organism Acidithiobacillus ferrivorans SS3

Toxin (Protein)


Gene name tacT Uniprot ID G0JMS1
Locus tag ACIFE_RS10005 Protein ID WP_014029456.1
Coordinates 2062750..2063244 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID G0JMS0
Locus tag ACIFE_RS10000 Protein ID WP_014029455.1
Coordinates 2062481..2062753 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIFE_RS09980 2059303..2060334 + 1032 WP_014029451.1 DNA-binding protein YbiB -
ACIFE_RS09985 2060349..2061134 + 786 WP_014029452.1 uroporphyrinogen-III C-methyltransferase -
ACIFE_RS09990 2061144..2061500 + 357 WP_014029453.1 CbiX/SirB N-terminal domain-containing protein -
ACIFE_RS09995 2061505..2062071 + 567 WP_014029454.1 ANTAR domain-containing protein -
ACIFE_RS10000 2062481..2062753 + 273 WP_014029455.1 DUF1778 domain-containing protein Antitoxin
ACIFE_RS10005 2062750..2063244 + 495 WP_014029456.1 GNAT family N-acetyltransferase Toxin
ACIFE_RS15870 2063363..2063932 - 570 WP_014029457.1 hypothetical protein -
ACIFE_RS10020 2064507..2065844 - 1338 WP_014029458.1 cardiolipin synthase B -
ACIFE_RS10025 2066075..2067745 - 1671 WP_014029459.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18213.96 Da        Isoelectric Point: 10.5110

>T25600 WP_014029456.1 NC_015942:2062750-2063244 [Acidithiobacillus ferrivorans SS3]
MSLKLSSPQALAATHLFGDFECGEPALDEWLKRRAMNNQLTGASRSFVVVDEENRVRGFYSMSAGAVSHQLANGSVRRNM
PDPVPVMVLGRLAVDRRAQGIKLGAAMLQDAVNRAITVSQNTRVRALLVHALHERAKQFYEHYGFQESPQHPMTLMLRLS
TVKA

Download         Length: 495 bp

>T25600 NC_015942:2062750-2063244 [Acidithiobacillus ferrivorans SS3]
ATGAGCTTGAAGCTATCCTCGCCGCAAGCACTTGCCGCGACGCATCTGTTCGGCGACTTTGAATGCGGAGAGCCTGCTCT
GGATGAGTGGCTCAAACGCCGGGCAATGAACAACCAGCTCACTGGCGCCAGCAGGAGTTTTGTGGTTGTTGATGAAGAAA
ATCGTGTGCGTGGCTTCTACTCCATGTCAGCTGGTGCGGTTTCTCATCAATTGGCGAACGGCTCAGTTCGTCGCAATATG
CCCGATCCGGTTCCCGTCATGGTGCTTGGCAGGCTGGCGGTAGATCGACGGGCACAAGGCATCAAACTGGGGGCAGCCAT
GCTACAAGACGCGGTAAATCGGGCCATCACCGTATCGCAGAACACCAGAGTTCGCGCTTTGCTGGTTCATGCGCTCCACG
AACGCGCCAAACAGTTCTATGAGCACTACGGCTTTCAGGAGTCACCACAACATCCGATGACGTTGATGCTACGCCTGAGT
ACCGTCAAAGCTTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10240.74 Da        Isoelectric Point: 4.7718

>AT25600 WP_014029455.1 NC_015942:2062481-2062753 [Acidithiobacillus ferrivorans SS3]
MRVAAINLRALPEQRDLIDYAANLLNKNRSDFMLEAACERAQSVLLDQVFFGLDAEKFQRFTAMLDAPPRANEGLERLMA
IKTPWESNQA

Download         Length: 273 bp

>AT25600 NC_015942:2062481-2062753 [Acidithiobacillus ferrivorans SS3]
ATGCGTGTTGCTGCCATCAATTTACGCGCCCTGCCGGAGCAACGTGATCTCATTGACTACGCCGCCAACCTGCTGAACAA
AAACCGTTCCGATTTCATGCTGGAAGCCGCCTGCGAGCGTGCGCAATCGGTGCTGCTCGACCAGGTGTTCTTTGGGCTGG
ATGCGGAAAAATTCCAGCGGTTCACCGCCATGCTTGATGCGCCGCCACGTGCCAATGAGGGTCTTGAGCGGTTGATGGCG
ATCAAGACGCCGTGGGAAAGCAATCAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7XQ51

Antitoxin

Source ID Structure
AlphaFold DB A0A1E7XQ54

References