Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 823732..824386 Replicon chromosome
Accession NZ_CP103645
Organism Escherichia coli strain 961

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag M5R18_RS04045 Protein ID WP_000244781.1
Coordinates 823979..824386 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M5R18_RS04040 Protein ID WP_000354046.1
Coordinates 823732..823998 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R18_RS04020 (819820) 819820..821253 - 1434 WP_001521235.1 6-phospho-beta-glucosidase BglA -
M5R18_RS04025 (821298) 821298..821609 + 312 WP_001182949.1 N(4)-acetylcytidine aminohydrolase -
M5R18_RS04030 (821773) 821773..822432 + 660 WP_000250269.1 hemolysin III family protein -
M5R18_RS04035 (822509) 822509..823489 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
M5R18_RS04040 (823732) 823732..823998 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M5R18_RS04045 (823979) 823979..824386 + 408 WP_000244781.1 protein YgfX Toxin
M5R18_RS04050 (824426) 824426..824947 - 522 WP_001521233.1 flavodoxin FldB -
M5R18_RS04055 (825059) 825059..825955 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5R18_RS04060 (825980) 825980..826690 + 711 WP_001521231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5R18_RS04065 (826696) 826696..828429 + 1734 WP_021523238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T255995 WP_000244781.1 NZ_CP103645:823979-824386 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT255995 WP_000354046.1 NZ_CP103645:823732-823998 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References