Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 34367..35106 Replicon plasmid pMB5921_1
Accession NZ_CP103643
Organism Enterobacter hormaechei strain 4453

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag M5S55_RS23200 Protein ID WP_013087269.1
Coordinates 34621..35106 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag M5S55_RS23195 Protein ID WP_007869691.1
Coordinates 34367..34633 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S55_RS23175 (M5S55_23175) 29922..30692 + 771 WP_047721744.1 TraX family protein -
M5S55_RS23180 (M5S55_23180) 30707..31030 + 324 WP_015572034.1 hypothetical protein -
M5S55_RS23185 (M5S55_23185) 31008..31811 - 804 WP_032670854.1 DUF4225 domain-containing protein -
M5S55_RS23190 (M5S55_23190) 32701..33714 - 1014 WP_045418235.1 plasmid replication initiator RepA -
M5S55_RS23195 (M5S55_23195) 34367..34633 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
M5S55_RS23200 (M5S55_23200) 34621..35106 + 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
M5S55_RS23205 (M5S55_23205) 35280..36683 + 1404 WP_000125668.1 ISNCY family transposase -
M5S55_RS23210 (M5S55_23210) 36716..37420 - 705 WP_000130816.1 arsenical resistance protein ArsH -
M5S55_RS23215 (M5S55_23215) 37507..37827 + 321 WP_000941305.1 transcriptional regulator -
M5S55_RS23220 (M5S55_23220) 37873..39162 + 1290 WP_000922628.1 arsenic transporter -
M5S55_RS23225 (M5S55_23225) 39175..39600 + 426 WP_000065802.1 glutaredoxin-dependent arsenate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-9 / aph(6)-Id / aph(3'')-Ib / dfrA19 / sul1 / qnrA1 / blaSHV-12 mrkB / mrkC / mrkD / mrkF / mrkJ 1..188203 188203
- flank IS/Tn - - 35280..36683 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T255992 WP_013087269.1 NZ_CP103643:34621-35106 [Enterobacter hormaechei]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT255992 WP_007869691.1 NZ_CP103643:34367-34633 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References