Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4680116..4680732 Replicon chromosome
Accession NZ_CP103642
Organism Enterobacter hormaechei strain 4453

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5S55_RS22595 Protein ID WP_015569913.1
Coordinates 4680116..4680487 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag M5S55_RS22600 Protein ID WP_015569912.1
Coordinates 4680490..4680732 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S55_RS22580 (M5S55_22580) 4677616..4678518 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
M5S55_RS22585 (M5S55_22585) 4678515..4679150 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
M5S55_RS22590 (M5S55_22590) 4679147..4680076 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
M5S55_RS22595 (M5S55_22595) 4680116..4680487 - 372 WP_015569913.1 PIN domain-containing protein Toxin
M5S55_RS22600 (M5S55_22600) 4680490..4680732 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
M5S55_RS22605 (M5S55_22605) 4680931..4681851 + 921 WP_015569911.1 alpha/beta hydrolase -
M5S55_RS22610 (M5S55_22610) 4681860..4682801 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
M5S55_RS22615 (M5S55_22615) 4682846..4683283 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
M5S55_RS22620 (M5S55_22620) 4683280..4684161 - 882 WP_003861949.1 virulence factor BrkB family protein -
M5S55_RS22625 (M5S55_22625) 4684155..4684754 - 600 WP_003861947.1 glucose-1-phosphatase -
M5S55_RS22630 (M5S55_22630) 4684873..4685673 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T255991 WP_015569913.1 NZ_CP103642:c4680487-4680116 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT255991 WP_015569912.1 NZ_CP103642:c4680732-4680490 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References