Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3800283..3800940 Replicon chromosome
Accession NZ_CP103642
Organism Enterobacter hormaechei strain 4453

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag M5S55_RS18360 Protein ID WP_017382887.1
Coordinates 3800283..3800693 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag M5S55_RS18365 Protein ID WP_003863437.1
Coordinates 3800674..3800940 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S55_RS18340 (M5S55_18340) 3796281..3798014 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
M5S55_RS18345 (M5S55_18345) 3798020..3798733 - 714 WP_023304384.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S55_RS18350 (M5S55_18350) 3798762..3799658 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
M5S55_RS18355 (M5S55_18355) 3799760..3800281 + 522 WP_015571793.1 flavodoxin FldB -
M5S55_RS18360 (M5S55_18360) 3800283..3800693 - 411 WP_017382887.1 protein YgfX Toxin
M5S55_RS18365 (M5S55_18365) 3800674..3800940 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
M5S55_RS18370 (M5S55_18370) 3801235..3802215 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
M5S55_RS18375 (M5S55_18375) 3802327..3802986 - 660 WP_003863433.1 hemolysin III family protein -
M5S55_RS18380 (M5S55_18380) 3803253..3803984 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
M5S55_RS18385 (M5S55_18385) 3804101..3805534 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T255990 WP_017382887.1 NZ_CP103642:c3800693-3800283 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT255990 WP_003863437.1 NZ_CP103642:c3800940-3800674 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References