Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1176841..1177461 Replicon chromosome
Accession NZ_CP103642
Organism Enterobacter hormaechei strain 4453

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag M5S55_RS05630 Protein ID WP_015571250.1
Coordinates 1176841..1177059 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag M5S55_RS05635 Protein ID WP_006809850.1
Coordinates 1177087..1177461 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S55_RS05600 (M5S55_05600) 1172853..1173113 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
M5S55_RS05605 (M5S55_05605) 1173116..1173256 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M5S55_RS05610 (M5S55_05610) 1173253..1173963 - 711 WP_023303201.1 GNAT family protein -
M5S55_RS05615 (M5S55_05615) 1174065..1175525 + 1461 WP_023303202.1 PLP-dependent aminotransferase family protein -
M5S55_RS05620 (M5S55_05620) 1175497..1175964 - 468 WP_017383209.1 YlaC family protein -
M5S55_RS05625 (M5S55_05625) 1176081..1176632 - 552 WP_023303203.1 maltose O-acetyltransferase -
M5S55_RS05630 (M5S55_05630) 1176841..1177059 - 219 WP_015571250.1 HHA domain-containing protein Toxin
M5S55_RS05635 (M5S55_05635) 1177087..1177461 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
M5S55_RS05640 (M5S55_05640) 1177972..1181118 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
M5S55_RS05645 (M5S55_05645) 1181141..1182334 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-114)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T255983 WP_015571250.1 NZ_CP103642:c1177059-1176841 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp


Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT255983 WP_006809850.1 NZ_CP103642:c1177461-1177087 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A837FFM2


Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References