Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2671970..2672709 Replicon chromosome
Accession NZ_CP103639
Organism Klebsiella aerogenes strain 722

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag M5T48_RS12690 Protein ID WP_032705770.1
Coordinates 2672224..2672709 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag M5T48_RS12685 Protein ID WP_015366659.1
Coordinates 2671970..2672236 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T48_RS12660 (M5T48_12660) 2667889..2668263 + 375 WP_259388004.1 ATP-binding protein -
M5T48_RS12665 (M5T48_12665) 2668263..2668880 + 618 WP_032705773.1 response regulator -
M5T48_RS12670 (M5T48_12670) 2668976..2669473 + 498 WP_015366656.1 heme-binding protein -
M5T48_RS12675 (M5T48_12675) 2669877..2670407 + 531 WP_047052402.1 N-acetyltransferase -
M5T48_RS12680 (M5T48_12680) 2670462..2671697 - 1236 WP_015366658.1 MFS transporter -
M5T48_RS12685 (M5T48_12685) 2671970..2672236 + 267 WP_015366659.1 DUF1778 domain-containing protein Antitoxin
M5T48_RS12690 (M5T48_12690) 2672224..2672709 + 486 WP_032705770.1 GNAT family N-acetyltransferase Toxin
M5T48_RS12695 (M5T48_12695) 2672781..2674397 + 1617 WP_015366662.1 FAD-NAD(P)-binding protein -
M5T48_RS12700 (M5T48_12700) 2674516..2675616 + 1101 WP_015366663.1 NADH:flavin oxidoreductase/NADH oxidase -
M5T48_RS12705 (M5T48_12705) 2675673..2675831 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
M5T48_RS12710 (M5T48_12710) 2676092..2677162 + 1071 WP_015366664.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T255977 WP_032705770.1 NZ_CP103639:2672224-2672709 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10075.52 Da        Isoelectric Point: 4.6558

>AT255977 WP_015366659.1 NZ_CP103639:2671970-2672236 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANSALDKLL
ARKPQWEK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References