Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 840975..841632 Replicon chromosome
Accession NZ_CP103639
Organism Klebsiella aerogenes strain 722

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag M5T48_RS04085 Protein ID WP_015369792.1
Coordinates 841222..841632 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag M5T48_RS04080 Protein ID WP_015369791.1
Coordinates 840975..841241 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T48_RS04055 (M5T48_04055) 836202..837635 - 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -
M5T48_RS04060 (M5T48_04060) 837755..838483 - 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
M5T48_RS04065 (M5T48_04065) 838534..838845 + 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
M5T48_RS04070 (M5T48_04070) 839010..839669 + 660 WP_008806429.1 hemolysin III family protein -
M5T48_RS04075 (M5T48_04075) 839768..840751 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
M5T48_RS04080 (M5T48_04080) 840975..841241 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
M5T48_RS04085 (M5T48_04085) 841222..841632 + 411 WP_015369792.1 protein YgfX Toxin
M5T48_RS04090 (M5T48_04090) 841640..842161 - 522 WP_015369793.1 flavodoxin FldB -
M5T48_RS04095 (M5T48_04095) 842262..843158 + 897 WP_015369794.1 site-specific tyrosine recombinase XerD -
M5T48_RS04100 (M5T48_04100) 843181..843894 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T48_RS04105 (M5T48_04105) 843900..845633 + 1734 WP_047051987.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T255972 WP_015369792.1 NZ_CP103639:841222-841632 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT255972 WP_015369791.1 NZ_CP103639:840975-841241 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References