Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4980233..4981914 Replicon chromosome
Accession NZ_CP103635
Organism Klebsiella pneumoniae strain 3221

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag M5T10_RS24340 Protein ID WP_002885155.1
Coordinates 4980233..4981150 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M5T10_RS24345 Protein ID WP_004177809.1
Coordinates 4981156..4981914 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T10_RS24320 (4975539) 4975539..4977059 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
M5T10_RS24325 (4977056) 4977056..4978054 + 999 WP_002885172.1 ribose ABC transporter permease -
M5T10_RS24330 (4978085) 4978085..4979026 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M5T10_RS24335 (4979101) 4979101..4980108 + 1008 WP_004177805.1 carbohydrate kinase family protein -
M5T10_RS24340 (4980233) 4980233..4981150 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M5T10_RS24345 (4981156) 4981156..4981914 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M5T10_RS24350 (4982000) 4982000..4982728 - 729 WP_004177810.1 response regulator transcription factor -
M5T10_RS24355 (4983001) 4983001..4985148 + 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
M5T10_RS24360 (4985378) 4985378..4986064 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T255968 WP_002885155.1 NZ_CP103635:c4981150-4980233 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT255968 WP_004177809.1 NZ_CP103635:c4981914-4981156 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References