Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4819771..4820287 Replicon chromosome
Accession NZ_CP103635
Organism Klebsiella pneumoniae strain 3221

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5T10_RS23535 Protein ID WP_004178374.1
Coordinates 4819771..4820055 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag M5T10_RS23540 Protein ID WP_032434351.1
Coordinates 4820045..4820287 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T10_RS23510 (4815254) 4815254..4815517 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M5T10_RS23515 (4815647) 4815647..4815820 + 174 WP_032414379.1 hypothetical protein -
M5T10_RS23520 (4815823) 4815823..4816566 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5T10_RS23525 (4816923) 4816923..4819061 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5T10_RS23530 (4819303) 4819303..4819767 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5T10_RS23535 (4819771) 4819771..4820055 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T10_RS23540 (4820045) 4820045..4820287 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5T10_RS23545 (4820365) 4820365..4822275 - 1911 WP_004152270.1 PRD domain-containing protein -
M5T10_RS23550 (4822298) 4822298..4823452 - 1155 WP_002886900.1 lactonase family protein -
M5T10_RS23555 (4823518) 4823518..4824258 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T255967 WP_004178374.1 NZ_CP103635:c4820055-4819771 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT255967 WP_032434351.1 NZ_CP103635:c4820287-4820045 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References