Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4727043..4727746 Replicon chromosome
Accession NZ_CP103635
Organism Klebsiella pneumoniae strain 3221

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag M5T10_RS23140 Protein ID WP_071994632.1
Coordinates 4727043..4727384 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag M5T10_RS23145 Protein ID WP_032434296.1
Coordinates 4727405..4727746 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T10_RS23130 (4723358) 4723358..4724227 + 870 WP_023317468.1 HNH endonuclease -
M5T10_RS23135 (4724818) 4724818..4726851 + 2034 WP_050598589.1 hypothetical protein -
M5T10_RS23140 (4727043) 4727043..4727384 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
M5T10_RS23145 (4727405) 4727405..4727746 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5T10_RS23150 (4727757) 4727757..4728299 - 543 WP_032434298.1 DNA repair protein RadC -
M5T10_RS23155 (4728312) 4728312..4728752 - 441 WP_032434300.1 antirestriction protein -
M5T10_RS23160 (4728783) 4728783..4729604 - 822 WP_032434301.1 DUF932 domain-containing protein -
M5T10_RS23165 (4729724) 4729724..4730197 - 474 WP_032434303.1 hypothetical protein -
M5T10_RS23170 (4730269) 4730269..4730721 - 453 WP_032410767.1 hypothetical protein -
M5T10_RS23175 (4730757) 4730757..4731473 - 717 WP_032434305.1 WYL domain-containing protein -
M5T10_RS23180 (4731717) 4731717..4732591 - 875 Protein_4542 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4715340..4761013 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T255966 WP_071994632.1 NZ_CP103635:c4727384-4727043 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT255966 WP_032434296.1 NZ_CP103635:c4727746-4727405 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References