Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1674039..1674700 Replicon chromosome
Accession NC_015942
Organism Acidithiobacillus ferrivorans SS3

Toxin (Protein)


Gene name vapC Uniprot ID G0JTG6
Locus tag ACIFE_RS08075 Protein ID WP_014029072.1
Coordinates 1674272..1674700 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0JTG5
Locus tag ACIFE_RS08070 Protein ID WP_014029071.1
Coordinates 1674039..1674272 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIFE_RS08050 1670696..1671202 - 507 WP_014029067.1 RES family NAD+ phosphorylase -
ACIFE_RS08055 1671166..1671606 - 441 WP_014029068.1 DUF2384 domain-containing protein -
ACIFE_RS08060 1671769..1673247 + 1479 WP_014029069.1 DNA-3-methyladenine glycosylase 2 family protein -
ACIFE_RS08065 1673244..1673768 - 525 WP_014029070.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
ACIFE_RS08070 1674039..1674272 + 234 WP_014029071.1 hypothetical protein Antitoxin
ACIFE_RS08075 1674272..1674700 + 429 WP_014029072.1 DNA-binding protein Toxin
ACIFE_RS08085 1674984..1675469 - 486 WP_014029073.1 Lrp/AsnC family transcriptional regulator -
ACIFE_RS08090 1675611..1677314 + 1704 WP_014029074.1 2-isopropylmalate synthase -
ACIFE_RS08095 1677318..1678142 - 825 WP_041649080.1 hypothetical protein -
ACIFE_RS08100 1678361..1679188 - 828 WP_014029076.1 hypothetical protein -
ACIFE_RS08105 1679196..1679396 - 201 WP_014029077.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15485.75 Da        Isoelectric Point: 6.2016

>T25596 WP_014029072.1 NC_015942:1674272-1674700 [Acidithiobacillus ferrivorans SS3]
MTFLLDVNVLIALIDPMHVQHDMAHEWFAAHGQPAWATCPLTENGVLRIVGHPRYPNSPGTPAAVAPLIQGLRASPGHVF
WPDDISLLDVDHIDASRLLTSGQITDSYLLALACAHEGQLATFDHRLVTNAVRNGLQCINKI

Download         Length: 429 bp

>T25596 NC_015942:1674272-1674700 [Acidithiobacillus ferrivorans SS3]
ATGACCTTCTTGCTCGATGTAAACGTGCTGATTGCGCTCATCGACCCCATGCATGTTCAGCATGATATGGCCCATGAATG
GTTTGCAGCCCATGGGCAACCCGCATGGGCTACCTGTCCCTTAACAGAGAATGGTGTACTGCGCATCGTGGGCCATCCGC
GCTATCCAAATTCACCAGGCACGCCAGCGGCAGTGGCACCGCTGATCCAGGGATTGCGCGCGTCACCTGGCCATGTTTTT
TGGCCAGACGACATCAGCCTGCTGGATGTCGACCATATCGACGCATCGCGCCTGCTCACTTCTGGTCAGATTACCGATAG
CTACCTCTTGGCGCTGGCCTGCGCCCATGAGGGCCAACTGGCAACCTTCGATCATCGCTTAGTGACCAATGCCGTGCGCA
ACGGTTTGCAATGCATCAACAAAATTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8172.36 Da        Isoelectric Point: 7.2027

>AT25596 WP_014029071.1 NC_015942:1674039-1674272 [Acidithiobacillus ferrivorans SS3]
MRTTLAIDDDVLAAAKGLADRQHKSVGAVVSALLRQALQPQNTSGGHSRNGIPLLPVRPDALPATLEIVNQLRDELP

Download         Length: 234 bp

>AT25596 NC_015942:1674039-1674272 [Acidithiobacillus ferrivorans SS3]
ATGCGCACCACACTGGCGATTGATGATGACGTACTGGCGGCAGCGAAAGGGCTGGCGGATCGACAGCATAAGTCTGTAGG
TGCCGTTGTTTCAGCACTTTTGCGGCAGGCGCTGCAACCACAAAACACCTCTGGTGGCCATTCACGTAATGGGATTCCCT
TGCTGCCGGTGCGCCCGGATGCACTCCCGGCGACTCTGGAAATAGTGAATCAGTTGCGCGACGAATTGCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7XU36

Antitoxin

Source ID Structure
AlphaFold DB G0JTG5

References