255943

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4523678..4524200 Replicon chromosome
Accession NZ_CP103633
Organism Escherichia coli strain 2900

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag M5S90_RS21740 Protein ID WP_001105433.1
Coordinates 4523678..4523968 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag M5S90_RS21745 Protein ID WP_000212715.1
Coordinates 4523958..4524200 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S90_RS21725 (4518841) 4518841..4520496 + 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -
M5S90_RS21730 (4520890) 4520890..4523028 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
M5S90_RS21735 (4523213) 4523213..4523677 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5S90_RS21740 (4523678) 4523678..4523968 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S90_RS21745 (4523958) 4523958..4524200 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5S90_RS21750 (4524392) 4524392..4524778 - 387 WP_001232246.1 cytochrome b562 -
M5S90_RS21755 (4524962) 4524962..4526314 - 1353 WP_001162173.1 metalloprotease PmbA -
M5S90_RS21760 (4526408) 4526408..4526959 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
M5S90_RS21765 (4527111) 4527111..4528484 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T255943 WP_001105433.1 NZ_CP103633:c4523968-4523678 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT255943 WP_000212715.1 NZ_CP103633:c4524200-4523958 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References