Detailed information of TA system TA255940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4010236..4011925
• Replicon: chromosome
• Accession: NZ_CP103633
• Organism: Escherichia coli strain 2900

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A829L165
• Locus tag: M5S90_RS19290
• Protein ID: WP_001521912.1
• Coordinates: 4010236..4011156 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: M5S90_RS19295
• Protein ID: WP_001521911.1
• Coordinates: 4011143..4011925 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M5S90_RS19275 (4006326)	4006326..4007453	-	1128	WP_001521913.1	MFS transporter	-
M5S90_RS19280 (4007595)	4007595..4008653	-	1059	WP_122452191.1	alpha/beta hydrolase	-
M5S90_RS19285 (4008918)	4008918..4009802	+	885	WP_001119037.1	LysR family transcriptional regulator	-
M5S90_RS19290 (4010236)	4010236..4011156	-	921	WP_001521912.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M5S90_RS19295 (4011143)	4011143..4011925	-	783	WP_001521911.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
M5S90_RS19300 (4012241)	4012241..4015450	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
M5S90_RS19305 (4015797)	4015797..4016267	+	471	WP_000201185.1	hypothetical protein	-
M5S90_RS19310 (4016264)	4016264..4016366	+	103	Protein_3781	helix-turn-helix domain-containing protein	-
M5S90_RS19315 (4016458)	4016458..4016616	+	159	Protein_3782	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34601.04 Da
• Isoelectric Point: 7.2649

>T255940 WP_001521912.1 NZ_CP103633:c4011156-4010236 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29168.46 Da
• Isoelectric Point: 8.4458

>AT255940 WP_001521911.1 NZ_CP103633:c4011925-4011143 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELVAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNGHPYFQFIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A829L165