Detailed information of TA system TA025594

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1503575..1504134
• Replicon: chromosome
• Accession: NC_015942
• Organism: Acidithiobacillus ferrivorans SS3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ACIFE_RS07170
• Protein ID: WP_202796643.1
• Coordinates: 1503575..1503877 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0JRP6
• Locus tag: ACIFE_RS07175
• Protein ID: WP_014028896.1
• Coordinates: 1503874..1504134 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACIFE_RS07145	1499279..1499938	+	660	WP_014028891.1	FMN-binding negative transcriptional regulator	-
ACIFE_RS07150	1499935..1500585	+	651	Protein_1422	DJ-1/PfpI family protein	-
ACIFE_RS07155	1500664..1501140	+	477	WP_041650697.1	GNAT family N-acetyltransferase	-
ACIFE_RS07160	1501146..1501955	+	810	WP_014028893.1	PhzF family phenazine biosynthesis protein	-
ACIFE_RS16275	1502159..1502569	+	411	WP_014028894.1	GFA family protein	-
ACIFE_RS07165	1502691..1503161	+	471	WP_014028895.1	signal peptidase II	-
ACIFE_RS07170	1503575..1503877	-	303	WP_202796643.1	type II toxin-antitoxin system VapC family toxin	Toxin
ACIFE_RS07175	1503874..1504134	-	261	WP_014028896.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
ACIFE_RS07180	1504240..1504500	-	261	WP_014028897.1	hypothetical protein	-
ACIFE_RS16280	1504693..1504815	-	123	WP_202796644.1	DUF86 domain-containing protein	-
ACIFE_RS07185	1504935..1506227	-	1293	WP_014028898.1	type II toxin-antitoxin system HipA family toxin	-
ACIFE_RS07190	1506230..1506475	-	246	WP_014028899.1	helix-turn-helix domain-containing protein	-
ACIFE_RS07195	1507075..1508785	+	1711	Protein_1433	DNA polymerase III subunit gamma/tau	-
ACIFE_RS07200	1508790..1509113	+	324	WP_014028901.1	YbaB/EbfC family nucleoid-associated protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-82)

Antitoxin

• SpoVT-AbrB domain (8-54)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11482.56 Da
• Isoelectric Point: 10.9565

>T25594 WP_202796643.1 NC_015942:c1503877-1503575 [Acidithiobacillus ferrivorans SS3]
VKLYMLDTNTVSHLLREHPVVTKRIVAVPMASLCISAITEGELLFGLAKRPTAKRLHVAVRQFLRRVDVLPWNSSTAEHY
GIVRADMEKRGRIHWRHLTC

Nucleotide

• Length: 303 bp

>T25594 NC_015942:c1503877-1503575 [Acidithiobacillus ferrivorans SS3]
GTGAAGTTGTACATGCTGGATACCAATACGGTAAGCCACCTGCTCAGAGAACATCCGGTCGTGACTAAGCGCATAGTGGC
GGTACCGATGGCGTCCCTTTGCATCTCTGCCATCACCGAAGGCGAGCTGCTTTTTGGTCTGGCCAAACGGCCGACCGCCA
AACGTCTTCACGTTGCCGTACGGCAGTTTCTCCGGCGCGTCGATGTGTTGCCCTGGAACAGCTCCACGGCAGAGCACTAC
GGGATTGTGCGGGCTGATATGGAGAAACGAGGCAGGATACACTGGCGTCACTTGACTTGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9849.00 Da
• Isoelectric Point: 5.1331

>AT25594 WP_014028896.1 NC_015942:c1504134-1503874 [Acidithiobacillus ferrivorans SS3]
MSQVAKLFTNGRSQAVRLPAAYRFDTKEVFIRKDSETGDVILSRKPANWDDFFVAIKSADVPADFLDEKERNQGTQDRDP
FEGYCK

Nucleotide

• Length: 261 bp

>AT25594 NC_015942:c1504134-1503874 [Acidithiobacillus ferrivorans SS3]
ATGAGCCAAGTAGCCAAACTATTCACCAATGGCCGCAGCCAGGCGGTGCGTTTGCCGGCCGCTTATCGGTTCGATACCAA
GGAAGTCTTTATCCGCAAGGACTCAGAAACGGGCGACGTAATTTTGTCTCGTAAACCGGCAAACTGGGATGACTTCTTCG
TTGCGATCAAGAGCGCCGATGTGCCCGCCGATTTTTTGGATGAGAAGGAGCGCAACCAGGGGACGCAGGATCGTGACCCC
TTTGAGGGATATTGCAAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1E7XSS7