Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3389185..3389890 Replicon chromosome
Accession NZ_CP103633
Organism Escherichia coli strain 2900

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M5S90_RS16485 Protein ID WP_000539521.1
Coordinates 3389185..3389571 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5S90_RS16490 Protein ID WP_001280945.1
Coordinates 3389561..3389890 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S90_RS16465 (3385189) 3385189..3385815 + 627 WP_020233670.1 glutathione S-transferase GstB -
M5S90_RS16470 (3385812) 3385812..3386927 - 1116 WP_000555050.1 aldose sugar dehydrogenase YliI -
M5S90_RS16475 (3387038) 3387038..3387421 - 384 WP_000497137.1 biofilm formation regulator BssR -
M5S90_RS16480 (3387634) 3387634..3388959 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
M5S90_RS16485 (3389185) 3389185..3389571 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S90_RS16490 (3389561) 3389561..3389890 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M5S90_RS16495 (3389960) 3389960..3391288 - 1329 WP_000086873.1 GGDEF domain-containing protein -
M5S90_RS16500 (3391296) 3391296..3393644 - 2349 WP_021523051.1 EAL domain-containing protein -
M5S90_RS16505 (3393822) 3393822..3394733 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T255938 WP_000539521.1 NZ_CP103633:3389185-3389571 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT255938 WP_001280945.1 NZ_CP103633:3389561-3389890 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References