255934

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2477477..2478003 Replicon chromosome
Accession NZ_CP103633
Organism Escherichia coli strain 2900

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag M5S90_RS11830 Protein ID WP_000323025.1
Coordinates 2477716..2478003 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag M5S90_RS11825 Protein ID WP_000534858.1
Coordinates 2477477..2477716 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S90_RS11795 (2472739) 2472739..2473353 + 615 WP_001265627.1 hypothetical protein -
M5S90_RS11800 (2473356) 2473356..2474378 + 1023 WP_000915483.1 DUF4868 domain-containing protein -
M5S90_RS11805 (2474883) 2474883..2475905 + 1023 Protein_2309 ISNCY family transposase -
M5S90_RS11810 (2476026) 2476026..2476175 + 150 WP_011443592.1 protein YdfW -
M5S90_RS11815 (2476612) 2476612..2476944 - 333 WP_001301033.1 FlxA-like family protein -
M5S90_RS11820 (2477147) 2477147..2477452 - 306 WP_001326990.1 protein YdfV -
M5S90_RS11825 (2477477) 2477477..2477716 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
M5S90_RS11830 (2477716) 2477716..2478003 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
M5S90_RS11835 (2478075) 2478075..2478230 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
M5S90_RS11840 (2478447) 2478447..2478698 + 252 WP_000980994.1 protein Rem -
M5S90_RS11845 (2478765) 2478765..2479043 + 279 WP_012304870.1 hypothetical protein -
M5S90_RS11850 (2479045) 2479045..2480094 + 1050 WP_001265199.1 DUF968 domain-containing protein -
M5S90_RS11855 (2480108) 2480108..2480860 + 753 WP_001047135.1 antitermination protein -
M5S90_RS11860 (2481138) 2481138..2481227 - 90 WP_120795389.1 hypothetical protein -
M5S90_RS11865 (2481282) 2481282..2481494 - 213 WP_000087756.1 cold shock-like protein CspF -
M5S90_RS11870 (2481795) 2481795..2482010 + 216 WP_000066484.1 cold shock-like protein CspB -
M5S90_RS11875 (2482461) 2482461..2482919 + 459 WP_000526135.1 IS200/IS605-like element IS200C family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2448627..2511606 62979
- flank IS/Tn - - 2482461..2482919 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T255934 WP_000323025.1 NZ_CP103633:2477716-2478003 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT255934 WP_000534858.1 NZ_CP103633:2477477-2477716 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References