Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1230922..1231754 Replicon chromosome
Accession NZ_CP103633
Organism Escherichia coli strain 2900

Toxin (Protein)


Gene name yeeV Uniprot ID F4TJC5
Locus tag M5S90_RS05875 Protein ID WP_001094452.1
Coordinates 1230922..1231296 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TJC4
Locus tag M5S90_RS05880 Protein ID WP_001285579.1
Coordinates 1231386..1231754 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S90_RS05850 (1226297) 1226297..1228549 - 2253 WP_021523230.1 alpha-amylase family glycosyl hydrolase -
M5S90_RS05860 (1229283) 1229283..1230128 - 846 WP_001290261.1 DUF4942 domain-containing protein -
M5S90_RS05865 (1230225) 1230225..1230422 - 198 WP_000772035.1 DUF957 domain-containing protein -
M5S90_RS05870 (1230434) 1230434..1230925 - 492 WP_000976868.1 DUF5983 family protein -
M5S90_RS05875 (1230922) 1230922..1231296 - 375 WP_001094452.1 TA system toxin CbtA family protein Toxin
M5S90_RS05880 (1231386) 1231386..1231754 - 369 WP_001285579.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5S90_RS05885 (1231834) 1231834..1232055 - 222 WP_000692345.1 DUF987 domain-containing protein -
M5S90_RS05890 (1232118) 1232118..1232594 - 477 WP_001186706.1 RadC family protein -
M5S90_RS05895 (1232610) 1232610..1233095 - 486 WP_000206669.1 antirestriction protein -
M5S90_RS05900 (1233187) 1233187..1234004 - 818 Protein_1153 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14014.86 Da        Isoelectric Point: 7.2920

>T255928 WP_001094452.1 NZ_CP103633:c1231296-1230922 [Escherichia coli]
MNTLPDTHVREASRCSSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSTDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13580.39 Da        Isoelectric Point: 7.3223

>AT255928 WP_001285579.1 NZ_CP103633:c1231754-1231386 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7YIM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8DWX2

References