Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 1098054..1098637 | Replicon | chromosome |
Accession | NZ_CP103633 | ||
Organism | Escherichia coli strain 2900 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | S1EZP4 |
Locus tag | M5S90_RS05185 | Protein ID | WP_000254738.1 |
Coordinates | 1098302..1098637 (+) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | S1P3W5 |
Locus tag | M5S90_RS05180 | Protein ID | WP_000581937.1 |
Coordinates | 1098054..1098302 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M5S90_RS05170 (1094394) | 1094394..1095694 | + | 1301 | Protein_1013 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
M5S90_RS05175 (1095742) | 1095742..1097976 | + | 2235 | WP_000226798.1 | GTP diphosphokinase | - |
M5S90_RS05180 (1098054) | 1098054..1098302 | + | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
M5S90_RS05185 (1098302) | 1098302..1098637 | + | 336 | WP_000254738.1 | endoribonuclease MazF | Toxin |
M5S90_RS05190 (1098709) | 1098709..1099500 | + | 792 | WP_001071643.1 | nucleoside triphosphate pyrophosphohydrolase | - |
M5S90_RS05195 (1099728) | 1099728..1101365 | + | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
M5S90_RS05200 (1101452) | 1101452..1102750 | + | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12098.04 Da Isoelectric Point: 8.2618
>T255926 WP_000254738.1 NZ_CP103633:1098302-1098637 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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