Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 942280..942934 Replicon chromosome
Accession NZ_CP103633
Organism Escherichia coli strain 2900

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag M5S90_RS04485 Protein ID WP_000244781.1
Coordinates 942527..942934 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M5S90_RS04480 Protein ID WP_000354046.1
Coordinates 942280..942546 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S90_RS04460 (938368) 938368..939801 - 1434 WP_001521235.1 6-phospho-beta-glucosidase BglA -
M5S90_RS04465 (939846) 939846..940157 + 312 WP_001182949.1 N(4)-acetylcytidine aminohydrolase -
M5S90_RS04470 (940321) 940321..940980 + 660 WP_000250269.1 hemolysin III family protein -
M5S90_RS04475 (941057) 941057..942037 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
M5S90_RS04480 (942280) 942280..942546 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M5S90_RS04485 (942527) 942527..942934 + 408 WP_000244781.1 protein YgfX Toxin
M5S90_RS04490 (942974) 942974..943495 - 522 WP_001521233.1 flavodoxin FldB -
M5S90_RS04495 (943607) 943607..944503 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5S90_RS04500 (944528) 944528..945238 + 711 WP_001521231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S90_RS04505 (945244) 945244..946977 + 1734 WP_021523238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T255925 WP_000244781.1 NZ_CP103633:942527-942934 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT255925 WP_000354046.1 NZ_CP103633:942280-942546 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References