Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 82712..83337 Replicon plasmid pMB6206_1
Accession NZ_CP103627
Organism Escherichia coli strain 4012

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5S78_RS23955 Protein ID WP_000911313.1
Coordinates 82939..83337 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag M5S78_RS23950 Protein ID WP_000450520.1
Coordinates 82712..82939 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S78_RS23950 (82712) 82712..82939 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
M5S78_RS23955 (82939) 82939..83337 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
M5S78_RS23960 (83346) 83346..85499 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
M5S78_RS23965 (85752) 85752..86483 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
M5S78_RS23970 (86515) 86515..87012 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-55 / tet(A) / aph(3')-Ia / dfrA14 / sul3 / ant(3'')-Ia / floR / aac(3)-IIa / sitABCD iutA / iucD / iucC / iucB / iucA 1..140136 140136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T255914 WP_000911313.1 NZ_CP103627:82939-83337 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT255914 WP_000450520.1 NZ_CP103627:82712-82939 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References