Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 975344..975781 Replicon chromosome
Accession NC_015942
Organism Acidithiobacillus ferrivorans SS3

Toxin (Protein)


Gene name hicA Uniprot ID G0JN18
Locus tag ACIFE_RS04485 Protein ID WP_014028382.1
Coordinates 975557..975781 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID G0JN17
Locus tag ACIFE_RS04480 Protein ID WP_014028381.1
Coordinates 975344..975553 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIFE_RS04450 970532..971074 + 543 WP_014028376.1 DinB family protein -
ACIFE_RS16180 971161..972707 + 1547 Protein_894 IS3 family transposase -
ACIFE_RS04470 973203..974546 + 1344 WP_202796634.1 group II intron reverse transcriptase/maturase -
ACIFE_RS04475 974655..975266 + 612 WP_014028380.1 hypothetical protein -
ACIFE_RS04480 975344..975553 + 210 WP_014028381.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ACIFE_RS04485 975557..975781 + 225 WP_014028382.1 type II toxin-antitoxin system HicA family toxin Toxin
ACIFE_RS04490 976236..976517 + 282 WP_014028383.1 DUF1778 domain-containing protein -
ACIFE_RS04495 976514..977044 + 531 WP_014028384.1 GNAT family N-acetyltransferase -
ACIFE_RS04500 977416..978024 + 609 WP_014028385.1 uracil-DNA glycosylase family protein -
ACIFE_RS04505 978093..979568 - 1476 WP_014028386.1 YdiU family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8353.88 Da        Isoelectric Point: 10.9142

>T25591 WP_014028382.1 NC_015942:975557-975781 [Acidithiobacillus ferrivorans SS3]
MGNIPVLKPNEVIAILIKLGFIEVRQRGSHKQFRDTAGRCTTVPFHQGRDISPILLRQIAKDIGLALDELLKHR

Download         Length: 225 bp

>T25591 NC_015942:975557-975781 [Acidithiobacillus ferrivorans SS3]
ATGGGCAATATTCCCGTTCTCAAGCCCAATGAAGTAATCGCTATTCTCATTAAACTCGGCTTCATCGAAGTCCGCCAACG
CGGATCACACAAACAATTCCGCGATACCGCAGGCCGCTGCACAACGGTTCCGTTTCATCAAGGTCGAGACATCTCCCCAA
TCTTGCTCCGTCAAATCGCCAAAGACATCGGCCTCGCGCTTGATGAGTTGCTCAAGCACAGATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7455.47 Da        Isoelectric Point: 4.0818

>AT25591 WP_014028381.1 NC_015942:975344-975553 [Acidithiobacillus ferrivorans SS3]
MKVYSAVIERCPQTGLFVGFVPGFPGAHSQGETLDEVNHNLHDVIAMLLEDGEPMLESEFVGVQNVAIA

Download         Length: 210 bp

>AT25591 NC_015942:975344-975553 [Acidithiobacillus ferrivorans SS3]
ATGAAAGTCTATTCAGCGGTAATTGAGCGGTGCCCACAAACTGGCCTGTTCGTTGGTTTTGTTCCTGGTTTTCCCGGCGC
TCATTCCCAGGGGGAAACGCTGGATGAAGTCAACCACAACCTGCACGATGTTATTGCAATGCTTCTGGAAGATGGCGAAC
CCATGCTGGAGTCCGAGTTTGTCGGGGTTCAAAACGTCGCCATCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7XQJ3

Antitoxin

Source ID Structure
AlphaFold DB A0A1E7XQE4

References