Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4372913..4373410 Replicon chromosome
Accession NZ_CP103626
Organism Escherichia coli strain 4012

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag M5S78_RS21225 Protein ID WP_001173343.1
Coordinates 4372913..4373086 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag M5S78_RS21230 Protein ID WP_001425728.1
Coordinates 4373114..4373410 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S78_RS21215 (4369583) 4369583..4371040 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
M5S78_RS21220 (4371277) 4371277..4372794 + 1518 WP_001295074.1 lysine--tRNA ligase -
M5S78_RS21225 (4372913) 4372913..4373086 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
M5S78_RS21230 (4373114) 4373114..4373410 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
M5S78_RS21235 (4373637) 4373637..4373909 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
M5S78_RS21240 (4373921) 4373921..4374151 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
M5S78_RS21245 (4374332) 4374332..4375963 + 1632 WP_001216487.1 sensor histidine kinase -
M5S78_RS21250 (4375960) 4375960..4376679 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T255908 WP_001173343.1 NZ_CP103626:c4373086-4372913 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT255908 WP_001425728.1 NZ_CP103626:c4373410-4373114 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References