255907

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4155216..4156030 Replicon chromosome
Accession NZ_CP103626
Organism Escherichia coli strain 4012

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag M5S78_RS20120 Protein ID WP_001054376.1
Coordinates 4155216..4155473 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag M5S78_RS20125 Protein ID WP_001309181.1
Coordinates 4155485..4156030 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S78_RS20095 (4150504) 4150504..4151610 + 1107 WP_023568191.1 N-acetylneuraminate epimerase -
M5S78_RS20100 (4151675) 4151675..4152655 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
M5S78_RS20105 (4152765) 4152765..4152970 + 206 Protein_3927 HNH endonuclease -
M5S78_RS20110 (4153238) 4153238..4154478 - 1241 Protein_3928 helicase YjhR -
M5S78_RS20115 (4154594) 4154594..4154725 + 132 WP_001309182.1 hypothetical protein -
M5S78_RS20120 (4155216) 4155216..4155473 + 258 WP_001054376.1 YjhX family toxin Toxin
M5S78_RS20125 (4155485) 4155485..4156030 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
M5S78_RS20130 (4156086) 4156086..4156832 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
M5S78_RS20135 (4157001) 4157001..4157219 + 219 Protein_3933 hypothetical protein -
M5S78_RS20140 (4157257) 4157257..4157373 + 117 Protein_3934 VOC family protein -
M5S78_RS20145 (4157618) 4157618..4158739 + 1122 WP_000010829.1 M42 family metallopeptidase -
M5S78_RS20150 (4158736) 4158736..4159014 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
M5S78_RS20155 (4159026) 4159026..4160339 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4145002..4164254 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T255907 WP_001054376.1 NZ_CP103626:4155216-4155473 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT255907 WP_001309181.1 NZ_CP103626:4155485-4156030 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References