Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3528921..3529539 Replicon chromosome
Accession NZ_CP103626
Organism Escherichia coli strain 4012

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5S78_RS17075 Protein ID WP_001291435.1
Coordinates 3529321..3529539 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5S78_RS17070 Protein ID WP_000344800.1
Coordinates 3528921..3529295 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S78_RS17060 (3524010) 3524010..3525203 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5S78_RS17065 (3525226) 3525226..3528375 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M5S78_RS17070 (3528921) 3528921..3529295 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5S78_RS17075 (3529321) 3529321..3529539 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5S78_RS17080 (3529711) 3529711..3530262 + 552 WP_000102568.1 maltose O-acetyltransferase -
M5S78_RS17085 (3530378) 3530378..3530848 + 471 WP_000136192.1 YlaC family protein -
M5S78_RS17090 (3531012) 3531012..3532562 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5S78_RS17095 (3532604) 3532604..3532957 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5S78_RS17105 (3533336) 3533336..3533647 + 312 WP_000409911.1 MGMT family protein -
M5S78_RS17110 (3533678) 3533678..3534250 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255906 WP_001291435.1 NZ_CP103626:3529321-3529539 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255906 WP_000344800.1 NZ_CP103626:3528921-3529295 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References