Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1362707..1363332 Replicon chromosome
Accession NZ_CP103626
Organism Escherichia coli strain 4012

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5S78_RS06675 Protein ID WP_000911330.1
Coordinates 1362934..1363332 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag M5S78_RS06670 Protein ID WP_000450524.1
Coordinates 1362707..1362934 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S78_RS06645 (1358510) 1358510..1358980 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
M5S78_RS06650 (1358980) 1358980..1359552 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
M5S78_RS06655 (1359698) 1359698..1360576 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
M5S78_RS06660 (1360593) 1360593..1361627 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
M5S78_RS06665 (1361840) 1361840..1362553 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
M5S78_RS06670 (1362707) 1362707..1362934 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
M5S78_RS06675 (1362934) 1362934..1363332 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
M5S78_RS06680 (1363479) 1363479..1364342 + 864 WP_001267507.1 neutral zinc metallopeptidase -
M5S78_RS06685 (1364357) 1364357..1366372 + 2016 WP_069354268.1 tRNA cytosine(34) acetyltransferase TmcA -
M5S78_RS06690 (1366446) 1366446..1367144 + 699 WP_000679812.1 esterase -
M5S78_RS06695 (1367254) 1367254..1367454 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T255899 WP_000911330.1 NZ_CP103626:1362934-1363332 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT255899 WP_000450524.1 NZ_CP103626:1362707-1362934 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References