255896

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871265..871919 Replicon chromosome
Accession NZ_CP103626
Organism Escherichia coli strain 4012

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag M5S78_RS04255 Protein ID WP_000244777.1
Coordinates 871512..871919 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M5S78_RS04250 Protein ID WP_000354046.1
Coordinates 871265..871531 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S78_RS04225 (866553) 866553..867296 + 744 WP_000951948.1 SDR family oxidoreductase -
M5S78_RS04230 (867353) 867353..868786 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
M5S78_RS04235 (868831) 868831..869142 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
M5S78_RS04240 (869306) 869306..869965 + 660 WP_000250274.1 hemolysin III family protein -
M5S78_RS04245 (870042) 870042..871022 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
M5S78_RS04250 (871265) 871265..871531 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M5S78_RS04255 (871512) 871512..871919 + 408 WP_000244777.1 protein YgfX Toxin
M5S78_RS04260 (871959) 871959..872480 - 522 WP_001055874.1 flavodoxin FldB -
M5S78_RS04265 (872592) 872592..873488 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5S78_RS04270 (873513) 873513..874223 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S78_RS04275 (874229) 874229..875962 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T255896 WP_000244777.1 NZ_CP103626:871512-871919 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT255896 WP_000354046.1 NZ_CP103626:871265-871531 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References