Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 263362..263948 Replicon chromosome
Accession NZ_CP103626
Organism Escherichia coli strain 4012

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag M5S78_RS01190 Protein ID WP_042014162.1
Coordinates 263362..263592 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag M5S78_RS01195 Protein ID WP_000593555.1
Coordinates 263589..263948 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S78_RS01180 (259399) 259399..262134 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
M5S78_RS01185 (262134) 262134..263258 + 1125 WP_001314210.1 ABC transporter permease -
M5S78_RS01190 (263362) 263362..263592 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
M5S78_RS01195 (263589) 263589..263948 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M5S78_RS01200 (264068) 264068..264469 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
M5S78_RS01205 (264475) 264475..265281 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
M5S78_RS01210 (265278) 265278..266042 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
M5S78_RS01215 (266042) 266042..266875 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
M5S78_RS01220 (266872) 266872..267816 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T255892 WP_042014162.1 NZ_CP103626:263362-263592 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT255892 WP_000593555.1 NZ_CP103626:263589-263948 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References