Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4187112..4187674 Replicon chromosome
Accession NZ_CP103623
Organism Escherichia coli strain 3985

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag M5T36_RS20180 Protein ID WP_053877263.1
Coordinates 4187112..4187429 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5T36_RS20185 Protein ID WP_001223208.1
Coordinates 4187423..4187674 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T36_RS20160 (4182558) 4182558..4183580 - 1023 WP_001368084.1 ABC transporter permease -
M5T36_RS20165 (4183594) 4183594..4185096 - 1503 WP_000210554.1 sugar ABC transporter ATP-binding protein -
M5T36_RS20170 (4185236) 4185236..4186192 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T36_RS20175 (4186502) 4186502..4187032 + 531 WP_000055075.1 inorganic diphosphatase -
M5T36_RS20180 (4187112) 4187112..4187429 - 318 WP_053877263.1 endoribonuclease toxin ChpB Toxin
M5T36_RS20185 (4187423) 4187423..4187674 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5T36_RS20190 (4187886) 4187886..4188227 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5T36_RS20195 (4188230) 4188230..4192009 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-104)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11289.00 Da        Isoelectric Point: 6.2152

>T255887 WP_053877263.1 NZ_CP103623:c4187429-4187112 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVE

Download         Length: 318 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT255887 WP_001223208.1 NZ_CP103623:c4187674-4187423 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References