255884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3487132..3487969 Replicon chromosome
Accession NZ_CP103623
Organism Escherichia coli strain 3985

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag M5T36_RS16855 Protein ID WP_000227784.1
Coordinates 3487427..3487969 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag M5T36_RS16850 Protein ID WP_001297137.1
Coordinates 3487132..3487443 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T36_RS16825 (3482152) 3482152..3483099 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
M5T36_RS16830 (3483121) 3483121..3485112 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
M5T36_RS16835 (3485102) 3485102..3485716 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
M5T36_RS16840 (3485716) 3485716..3486045 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
M5T36_RS16845 (3486057) 3486057..3486947 + 891 WP_000971332.1 heme o synthase -
M5T36_RS16850 (3487132) 3487132..3487443 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
M5T36_RS16855 (3487427) 3487427..3487969 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
M5T36_RS16860 (3488025) 3488025..3488960 - 936 WP_001297127.1 tetratricopeptide repeat protein -
M5T36_RS16865 (3489368) 3489368..3490732 + 1365 WP_001000978.1 MFS transporter -
M5T36_RS16870 (3490860) 3490860..3491351 - 492 WP_001138904.1 nucleotide binding protein YajQ -
M5T36_RS16875 (3491519) 3491519..3492430 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T255884 WP_000227784.1 NZ_CP103623:3487427-3487969 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT255884 WP_001297137.1 NZ_CP103623:3487132-3487443 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References