Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3453056..3453674 Replicon chromosome
Accession NZ_CP103623
Organism Escherichia coli strain 3985

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T36_RS16685 Protein ID WP_001291435.1
Coordinates 3453456..3453674 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E9TLB8
Locus tag M5T36_RS16680 Protein ID WP_000344794.1
Coordinates 3453056..3453430 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T36_RS16670 (3448145) 3448145..3449338 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T36_RS16675 (3449361) 3449361..3452510 + 3150 WP_001132470.1 efflux RND transporter permease AcrB -
M5T36_RS16680 (3453056) 3453056..3453430 + 375 WP_000344794.1 Hha toxicity modulator TomB Antitoxin
M5T36_RS16685 (3453456) 3453456..3453674 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T36_RS16690 (3453845) 3453845..3454396 + 552 WP_000102564.1 maltose O-acetyltransferase -
M5T36_RS16695 (3454512) 3454512..3454982 + 471 WP_000136192.1 YlaC family protein -
M5T36_RS16700 (3455146) 3455146..3456696 + 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T36_RS16705 (3456738) 3456738..3457091 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5T36_RS16715 (3457470) 3457470..3457781 + 312 WP_000409911.1 MGMT family protein -
M5T36_RS16720 (3457812) 3457812..3458384 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255883 WP_001291435.1 NZ_CP103623:3453456-3453674 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.36 Da        Isoelectric Point: 4.9284

>AT255883 WP_000344794.1 NZ_CP103623:3453056-3453430 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGRVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References