Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2486247..2486885 Replicon chromosome
Accession NZ_CP103623
Organism Escherichia coli strain 3985

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag M5T36_RS12095 Protein ID WP_000813794.1
Coordinates 2486709..2486885 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5T36_RS12090 Protein ID WP_001270285.1
Coordinates 2486247..2486663 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T36_RS12070 (2481399) 2481399..2482340 - 942 WP_001251313.1 ABC transporter permease -
M5T36_RS12075 (2482341) 2482341..2483354 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
M5T36_RS12080 (2483372) 2483372..2484517 - 1146 WP_000034363.1 ABC transporter substrate-binding protein -
M5T36_RS12085 (2484762) 2484762..2486168 - 1407 WP_000760590.1 PLP-dependent aminotransferase family protein -
M5T36_RS12090 (2486247) 2486247..2486663 - 417 WP_001270285.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5T36_RS12095 (2486709) 2486709..2486885 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5T36_RS12100 (2487107) 2487107..2487337 + 231 WP_000494244.1 YncJ family protein -
M5T36_RS12105 (2487429) 2487429..2489390 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5T36_RS12110 (2489463) 2489463..2489999 - 537 WP_000429153.1 DNA-binding transcriptional regulator SutR -
M5T36_RS12115 (2490091) 2490091..2491266 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2491306..2492454 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T255882 WP_000813794.1 NZ_CP103623:c2486885-2486709 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.61 Da        Isoelectric Point: 4.6115

>AT255882 WP_001270285.1 NZ_CP103623:c2486663-2486247 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References