Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1346096..1346721 Replicon chromosome
Accession NZ_CP103623
Organism Escherichia coli strain 3985

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag M5T36_RS06585 Protein ID WP_000911329.1
Coordinates 1346323..1346721 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag M5T36_RS06580 Protein ID WP_000450524.1
Coordinates 1346096..1346323 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T36_RS06555 (1341898) 1341898..1342368 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
M5T36_RS06560 (1342368) 1342368..1342940 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
M5T36_RS06565 (1343086) 1343086..1343964 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
M5T36_RS06570 (1343981) 1343981..1345015 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
M5T36_RS06575 (1345228) 1345228..1345941 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
M5T36_RS06580 (1346096) 1346096..1346323 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
M5T36_RS06585 (1346323) 1346323..1346721 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
M5T36_RS06590 (1346868) 1346868..1347731 + 864 WP_001267498.1 neutral zinc metallopeptidase -
M5T36_RS06595 (1347746) 1347746..1349761 + 2016 WP_000829295.1 tRNA cytosine(34) acetyltransferase TmcA -
M5T36_RS06600 (1349835) 1349835..1350533 + 699 WP_000679823.1 esterase -
M5T36_RS06605 (1350643) 1350643..1350843 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T255875 WP_000911329.1 NZ_CP103623:1346323-1346721 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT255875 WP_000450524.1 NZ_CP103623:1346096-1346323 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References