Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 848121..848775 Replicon chromosome
Accession NZ_CP103623
Organism Escherichia coli strain 3985

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag M5T36_RS04155 Protein ID WP_000244772.1
Coordinates 848368..848775 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M5T36_RS04150 Protein ID WP_000354046.1
Coordinates 848121..848387 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T36_RS04125 (843290) 843290..844033 + 744 WP_000951941.1 SDR family oxidoreductase -
M5T36_RS04130 (844090) 844090..845523 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
M5T36_RS04135 (845568) 845568..845879 + 312 WP_001182945.1 N(4)-acetylcytidine aminohydrolase -
M5T36_RS04140 (846043) 846043..846702 + 660 WP_000250274.1 hemolysin III family protein -
M5T36_RS04145 (846898) 846898..847878 - 981 WP_000886095.1 tRNA-modifying protein YgfZ -
M5T36_RS04150 (848121) 848121..848387 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M5T36_RS04155 (848368) 848368..848775 + 408 WP_000244772.1 protein YgfX Toxin
M5T36_RS04160 (848815) 848815..849336 - 522 WP_001055874.1 flavodoxin FldB -
M5T36_RS04165 (849448) 849448..850344 + 897 WP_000806637.1 site-specific tyrosine recombinase XerD -
M5T36_RS04170 (850369) 850369..851079 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T36_RS04175 (851085) 851085..852818 + 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T255873 WP_000244772.1 NZ_CP103623:848368-848775 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT255873 WP_000354046.1 NZ_CP103623:848121-848387 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References