Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 806534..807191 Replicon chromosome
Accession NZ_CP103621
Organism Klebsiella pneumoniae strain 433

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag M5S60_RS04040 Protein ID WP_040245400.1
Coordinates 806781..807191 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5S60_RS04035 Protein ID WP_002916312.1
Coordinates 806534..806800 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S60_RS04010 (801690) 801690..803123 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M5S60_RS04015 (803242) 803242..803970 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5S60_RS04020 (804020) 804020..804331 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5S60_RS04025 (804495) 804495..805154 + 660 WP_048334397.1 hemolysin III family protein -
M5S60_RS04030 (805305) 805305..806288 - 984 WP_032430613.1 tRNA-modifying protein YgfZ -
M5S60_RS04035 (806534) 806534..806800 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5S60_RS04040 (806781) 806781..807191 + 411 WP_040245400.1 protein YgfX Toxin
M5S60_RS04045 (807198) 807198..807719 - 522 WP_002916308.1 flavodoxin FldB -
M5S60_RS04050 (807820) 807820..808716 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5S60_RS04055 (808739) 808739..809452 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S60_RS04060 (809458) 809458..811191 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T255859 WP_040245400.1 NZ_CP103621:806781-807191 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT255859 WP_002916312.1 NZ_CP103621:806534-806800 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References