Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4864197..4864713 Replicon chromosome
Accession NZ_CP103618
Organism Klebsiella pneumoniae strain 4383

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5T08_RS23555 Protein ID WP_004178374.1
Coordinates 4864197..4864481 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5T08_RS23560 Protein ID WP_002886901.1
Coordinates 4864471..4864713 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T08_RS23530 (4859681) 4859681..4859944 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
M5T08_RS23535 (4860074) 4860074..4860247 + 174 WP_032408826.1 hypothetical protein -
M5T08_RS23540 (4860250) 4860250..4860993 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5T08_RS23545 (4861350) 4861350..4863488 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5T08_RS23550 (4863729) 4863729..4864193 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5T08_RS23555 (4864197) 4864197..4864481 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T08_RS23560 (4864471) 4864471..4864713 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5T08_RS23565 (4864791) 4864791..4866701 - 1911 WP_004178373.1 PRD domain-containing protein -
M5T08_RS23570 (4866724) 4866724..4867878 - 1155 WP_004178372.1 lactonase family protein -
M5T08_RS23575 (4867945) 4867945..4868685 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T255852 WP_004178374.1 NZ_CP103618:c4864481-4864197 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT255852 WP_002886901.1 NZ_CP103618:c4864713-4864471 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References