Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 692590..693269 Replicon chromosome
Accession NZ_CP103618
Organism Klebsiella pneumoniae strain 4383

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag M5T08_RS03400 Protein ID WP_020324801.1
Coordinates 692928..693269 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag M5T08_RS03395 Protein ID WP_020324792.1
Coordinates 692590..692907 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T08_RS03370 (687805) 687805..690957 + 3153 WP_022631414.1 AIDA repeat-containing protein -
M5T08_RS03375 (691050) 691050..691289 + 240 WP_020324820.1 DUF905 domain-containing protein -
M5T08_RS03380 (691392) 691392..691849 + 458 Protein_664 antirestriction protein -
M5T08_RS03385 (691865) 691865..692341 + 477 WP_020324797.1 RadC family protein -
M5T08_RS03390 (692350) 692350..692577 + 228 WP_020324796.1 DUF987 domain-containing protein -
M5T08_RS03395 (692590) 692590..692907 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5T08_RS03400 (692928) 692928..693269 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
M5T08_RS03405 (693385) 693385..694218 + 834 WP_259387827.1 DUF4942 domain-containing protein -
M5T08_RS03415 (694521) 694521..695027 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
M5T08_RS03420 (695127) 695127..696968 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T255841 WP_020324801.1 NZ_CP103618:692928-693269 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT255841 WP_020324792.1 NZ_CP103618:692590-692907 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References