Detailed information of TA system TA025584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 51819..52321
• Replicon: chromosome
• Accession: NC_015942
• Organism: Acidithiobacillus ferrivorans SS3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: G0JQ43
• Locus tag: ACIFE_RS00195
• Protein ID: WP_014027555.1
• Coordinates: 52067..52321 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0JQ42
• Locus tag: ACIFE_RS00190
• Protein ID: WP_014027554.1
• Coordinates: 51819..52070 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACIFE_RS00165	46952..47311	-	360	WP_014027549.1	dihydroneopterin aldolase	-
ACIFE_RS00170	47384..47980	+	597	WP_014027550.1	glycerol-3-phosphate 1-O-acyltransferase PlsY	-
ACIFE_RS00175	48009..49022	-	1014	WP_014027551.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	-
ACIFE_RS00180	49019..49846	-	828	WP_014027552.1	ferritin-like domain-containing protein	-
ACIFE_RS00185	49965..51476	-	1512	WP_014027553.1	PQQ-binding-like beta-propeller repeat protein	-
ACIFE_RS00190	51819..52070	+	252	WP_014027554.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ACIFE_RS00195	52067..52321	+	255	WP_014027555.1	Txe/YoeB family addiction module toxin	Toxin
ACIFE_RS00200	52686..52931	+	246	WP_014027556.1	Arc family DNA-binding protein	-
ACIFE_RS00205	52928..53323	+	396	WP_014027557.1	type II toxin-antitoxin system VapC family toxin	-
ACIFE_RS00215	53782..54060	-	279	WP_014027558.1	hypothetical protein	-
ACIFE_RS00220	54032..54322	-	291	WP_014027559.1	BrnT family toxin	-
ACIFE_RS00225	54500..54895	+	396	WP_202796627.1	transposase	-
ACIFE_RS00230	55206..55649	-	444	WP_014027560.1	hypothetical protein	-
ACIFE_RS00235	55744..56160	-	417	WP_041648246.1	TIGR04141 family sporadically distributed protein	-
ACIFE_RS00240	56164..56619	-	456	WP_014027561.1	hypothetical protein	-
ACIFE_RS00245	56710..57102	-	393	WP_196762988.1	NUDIX domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10214.64 Da
• Isoelectric Point: 8.5039

>T25584 WP_014027555.1 NC_015942:52067-52321 [Acidithiobacillus ferrivorans SS3]
VRLIFSDDAWEDYLYWQKQDQRMVERINKLIRETQREPFAGVGKPEALKHALSGFWSRRTTDEHRMVYRIEGDALMIAQL
RFHY

Nucleotide

• Length: 255 bp

>T25584 NC_015942:52067-52321 [Acidithiobacillus ferrivorans SS3]
GTGAGGCTGATCTTCTCTGACGATGCATGGGAAGACTACCTATATTGGCAGAAGCAAGACCAGCGCATGGTCGAGCGAAT
CAATAAGCTGATACGTGAGACACAGCGTGAACCCTTCGCGGGAGTTGGCAAACCCGAAGCACTGAAGCATGCTCTTTCAG
GATTTTGGTCACGCCGTACTACAGATGAGCATCGCATGGTGTATCGAATAGAAGGTGATGCATTGATGATTGCTCAGTTG
CGTTTCCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9176.55 Da
• Isoelectric Point: 5.8124

>AT25584 WP_014027554.1 NC_015942:51819-52070 [Acidithiobacillus ferrivorans SS3]
MDAITYTTVRANLASAMDRVCDDHEPLIITRNGEQSVVMLSLEDYKALEETAYLLRTPANAKRLLAAVAQLNADKGVERK
LAK

Nucleotide

• Length: 252 bp

>AT25584 NC_015942:51819-52070 [Acidithiobacillus ferrivorans SS3]
ATGGATGCGATTACCTATACCACCGTTCGTGCAAACCTCGCCAGCGCCATGGACCGCGTTTGCGACGACCACGAACCCTT
GATCATTACCCGCAATGGCGAACAGTCCGTCGTGATGCTCTCGCTCGAAGACTACAAGGCGCTGGAGGAAACCGCCTACC
TCTTGCGTACCCCCGCCAACGCCAAGCGCCTTCTCGCTGCCGTCGCACAACTGAACGCCGATAAGGGCGTTGAGCGGAAG
CTGGCGAAGTGA

Structures

Toxin

• AlphaFold DB: G0JQ43

Antitoxin

• AlphaFold DB: G0JQ42