Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4766506..4767022 Replicon chromosome
Accession NZ_CP103614
Organism Klebsiella pneumoniae strain 3571

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5T29_RS23170 Protein ID WP_004178374.1
Coordinates 4766506..4766790 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5T29_RS23175 Protein ID WP_002886901.1
Coordinates 4766780..4767022 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T29_RS23145 (M5T29_23145) 4761923..4762186 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M5T29_RS23150 (M5T29_23150) 4762316..4762489 + 174 WP_019725541.1 hypothetical protein -
M5T29_RS23155 (M5T29_23155) 4762492..4763235 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5T29_RS23160 (M5T29_23160) 4763592..4765730 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5T29_RS23165 (M5T29_23165) 4766038..4766502 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5T29_RS23170 (M5T29_23170) 4766506..4766790 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T29_RS23175 (M5T29_23175) 4766780..4767022 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5T29_RS23180 (M5T29_23180) 4767100..4769010 - 1911 WP_048299762.1 PRD domain-containing protein -
M5T29_RS23185 (M5T29_23185) 4769033..4770187 - 1155 WP_002886900.1 lactonase family protein -
M5T29_RS23190 (M5T29_23190) 4770254..4770994 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T255836 WP_004178374.1 NZ_CP103614:c4766790-4766506 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT255836 WP_002886901.1 NZ_CP103614:c4767022-4766780 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References